Possible association between lipid profile and uterine fibroid size

Background: Uterine fibroid is the most common benign tumor in reproductive age group, arising from single smooth muscle cell of uterus. Steroid hormones, estrogen, and progesterone are considered to be important links pathophysiology uterine fibroid; meanwhile estrogens influence several aspects lipid metabolism; so it's possible theorize a relationship between size dyslipidemia. Aim study was evaluate association profile with size. Methods: This cross sectional performed Babylon Teaching Hospital for Maternity Pediatrics during period 1st March 2020- December 2020. included one hundred women diagnosed using abdominal and/or transvaginal ultrasound, fifty patients large fibroids ≥5cm3, small fibroid<5cm3. Serum measured both groups fasting state comparison. Results: The complaint abnormal bleeding groups. body mass index were 20-29.9; significant difference group1 that showed lower levels high-density lipoprotein 40.82±9.4, higher low-density 94.79±35.07 total serum cholesterol 155.7±43.63 group 2 level high density 50.7±6.55, low 51.49±15.2 123.2±14.18 p value <0.001.while non-significant two term very 0.878 triglyceride 0.879. Conclusions: Dyslipidemia form lipoprotein, significantly associated increased fibroid.